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Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 327-334 doi: 10.1007/s11684-019-0712-x

Abstract: This study aimed to investigate the prevalence, clinical characteristics, and prognostic impact of 1p32.3Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly moreUnivariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies (median PFSMultivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFSPatients with del(1p32.3) under bortezomib-based treatments tended to have short PFS and OS.

Keywords： 1p32.3 deletion     1q21 gain     prognosis     multiple myeloma     FISH     bortezomib     thalidomide    

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The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 211-215 doi: 10.1007/s11684-008-0041-y

Abstract: aberrations between primary HCC tumors and their matched metastatic lesions, and found that chromosome 8pBy the more sensitive genome-wide microsatellite analysis, 8p deletion was defined to 8p23.3 and 8p11.2Using ‘8p-specific’ microarrays, two novel metastatic suppressors ( and ) were identified, and were provenClinical studies indicate that 8p deletion detected in HCC or circulating plasma DNA of patients is a

Keywords： sensitive genome-wide     prediction     genome-wide microsatellite     frequency     Hepatocellular carcinoma    

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RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 81-86 doi: 10.15302/J-FASE-2016088

Abstract: As virulence-determining genes, and encode the small subunit and large subunit of viral ribonucleotide reductase (RR) in pseudorabies virus which have been extensively studied in mice. However, their role in pigs has not been adequately investigated. In this study, we deleted and genes based on a / / triple gene-deleted pseudorabies virus and tested its efficacy in pigs as a vaccine candidate. The rescued virus showed similar growth properties and plaque size as its parent strain. In an animal study, the virus could elicit humoral immune responses shown by generation of gB-specific antibodies and virus neutralizing antibodies. However, vaccination could not provide protection against virulent pseudorabies virus challenge since vaccinated pigs showed clinical pseudorabies-specific syndromes. The deficiency in protection may due to the generation of late and low levels of gB antibodies and virus neutralizing antibodies.

Keywords： pseudorabies virus     RR1 and RR2     ribonucleotide reductase     vaccine candidate    

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Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 123-138 doi: 10.1007/s11705-022-2194-7

Abstract: The two-electron cytoplasmic reductase NAD(P)H:quinone oxidoreductase 1 is expressed in many tissues.NAD(P)H:quinone oxidoreductase 1 is well-known for being highly expressed in most cancers.quinone oxidoreductase 1 to diagnose tumours.H:quinone oxidoreductase 1-activating drug β-lapachone.H:quinone oxidoreductase 1.

Keywords： NAD(P)H:quinone oxidoreductase 1     cancer therapy     target     probe     nanosystem    

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Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 305-317 doi: 10.1007/s11684-019-0722-8

Abstract: In mice, the IL-36a expression level markedly increased starting from postnatal day 0 (P0), and thisincrease occurred much earlier than those of TNF- , IL-23A, IL-1 and TLR4.the small proline-rich protein 2 family, in the skin tissues of the mice was also upregulated on P0

Keywords： acne inversa mouse model     interleukin 1 family     member 6     small proline rich protein 2D     key inflammatory    

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noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-relatedEVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting

Keywords： ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

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Synthesis of zeolite Na-P1 from coal fly ash produced by gasification and its application as adsorbent

Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 518-527 doi: 10.1007/s11705-020-1926-9

Abstract: The coal fly ash produced by gasification is estimated to be over 80 million ton per year in China by 2021. It has mainly been disposed as solid waste by landfill. There is lack of study focused on its utilization. In this paper, the coal fly ash produced by gasification was at first analyzed and then applied to synthesize zeolite as an adsorbent. The effects of synthesis conditions on the cation exchange capacity (CEC) of zeolite were investigated. The results from X-ray diffraction and scanning electron microscope indicated that the crystallinity of the synthesized zeolite is the most important factor to affect the CEC. When the synthesized zeolite with the highest CEC (275.5 meq/100 g) was used for the adsorption of Cr(VI) from aqueous solution, the maximum adsorption capacity for Cr(VI) was found to be 17.924 mg/g. The effects of pH, contact time and initial concentration on the adsorption of Cr(VI) were also investigated. The adsorption kinetics and isotherms can be well described by the pseudo-second-order model and Langmuir isotherm model, respectively.

Keywords： coal fly ash     gasification     zeolite     Na-P1     chromium(VI)    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract: <p>We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenp>

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Deciphering the Origins of P1-Induced Power Losses in Cu(Inx,Ga1–x Article

César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa

Engineering 2020, Volume 6, Issue 12,   Pages 1395-1402 doi: 10.1016/j.eng.2019.12.019

Abstract: Specifically, by analyzing the standard P1 patterning line ablated before the CIGS deposition, we revealWe further rationalize the origins of this effect by comparing the topography of the P1 edge throughWe also investigate the laser-induced damage on P1 patterning lines performed after the deposition ofOur findings pave the way for a better understanding of P1-induced power losses and introduce new insightsp>

Keywords： Cu(Inx     Ga1-x)Se2     Cell-to-module efficiency gap     P1-induced power losses     Hyperspectral photoluminescence    

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Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 1,   Pages 52-57 doi: 10.1007/s11705-009-0087-7

Abstract: The aim of this work was to separate 1,3-PDO from a synthetic mixture using polymeric resins, AmberliteThe equilibrium adsorption of 1,3-PDO onto two polymeric resins were investigated in binary and tertiary-PDO at 160 g/L onto XAD-7 and XAD-16 was 835.96 and 584.61 mg 1,3-PDO/g dry resin, respectively.The value of n of 1,3-PDO adsorbed on XAD-7 are much higher than those on XAD-16.than XAD-16, the adsorption capacity of 1,3-PDO at 160 g/L onto XAD-16 was higher than XAD-7.

Keywords： adsorption     1     3-propanediol     glycerol     polymeric resin     adsorption isotherm    

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Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 410-419 doi: 10.1007/s11684-016-0489-0

Abstract: <p>NUP98 fuses with approximately 34 different partner genes via translocation in hematologicalHerein, we demonstrated the association of NUP98-IQCG with CRM1, and found that NUP98-IQCG expressioninhibits the CRM1-mediated nuclear export of p65 and enhances the transcriptional activity of nuclearTherefore, the inhibition of nuclear exports of p65 and IQCG might contribute to the leukemogenesis ofp>

Keywords： NUP98-IQCG     nuclear export     NF-κB     CRM1    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associatedwith p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010).DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53.

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Modelling the dynamic response of a solid oxide steam electrolyser to transient inputs during renewable hydrogen production

Qiong CAI, Nigel P. BRANDON, Claire S. ADJIMAN,

Frontiers in Energy 2010, Volume 4, Issue 2,   Pages 211-222 doi: 10.1007/s11708-010-0037-6

Abstract: In this paper, a one-dimensional (1D) dynamic model of a planar SOEC stack has been employed to study

Keywords： hydrogen production     renewable energy     solid oxide electrolyser cell     1D dynamic model     dynamic behaviour    

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A simple umbelliferone based fluorescent probe for the detection of nitroreductase

P. Elmes, Tony D. James

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 311-314 doi: 10.1007/s11705-017-1697-0

Abstract: A simple nitrobenzyl-umbelliferone (NCOU1) was synthesised containing a nitroreductase (NTR) triggerIn the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity atThese results indicate that NCOU1 can be used as a simple assay for the detection of NTR.

Keywords： fragmentation     NCOU1     NTR     nitroreductase     nitrobenzyl-umbelliferone    

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Title Author Date Type Operation

Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Journal Article

The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary

QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning

Journal Article

RR1 and RR2 gene deletion affects the immunogenicity of a live attenuated pseudorabies

Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN

Journal Article

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Journal Article

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue Zhang

Journal Article

noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis

Journal Article

Synthesis of zeolite Na-P1 from coal fly ash produced by gasification and its application as adsorbent

Yixin Zhang, Lu Zhou, Liqing Chen, Yang Guo, Fanhui Guo, Jianjun Wu, Baiqian Dai

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Deciphering the Origins of P1-Induced Power Losses in Cu(Inx,Ga1–x

César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa

Journal Article

Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

TANTAYAKOM, P. PRASITCHOKE, C. MUANGNAPOH

Journal Article

Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG

Mengmeng Pan,Qiyao Zhang,Ping Liu,Jinyan Huang,Yueying Wang,Saijuan Chen

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article

Modelling the dynamic response of a solid oxide steam electrolyser to transient inputs during renewable hydrogen production

Qiong CAI, Nigel P. BRANDON, Claire S. ADJIMAN,

Journal Article

A simple umbelliferone based fluorescent probe for the detection of nitroreductase

P. Elmes, Tony D. James

Journal Article

construction integration technology in Brazil’s superlarge deep-water offshore oil and gas unit project (FPSO P67/P70)

Journal Article